Metabolism of no-carrier-added 2-[18F]fluoro-L-tyrosine in rats
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Metabolism of no-carrier-added 2-[18F]fluoro-L-tyrosine in rats
BACKGROUND Several fluorine-18 labelled fluoroamino acids have been evaluated as tracers for the quantitative assessment of cerebral protein synthesis in vivo by positron emission tomography (PET). Among these, 2-[18F]fluoro-L-tyrosine (2-[18F]Tyr) has been studied in mice at a low specific activity. Its incorporation into proteins is fast and metabolism via other pathways is limited. The prese...
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4-[(18)F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[(18)F]fluorophenoxy moiety. In order to prepare 4-[(18)F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [(18)F]fluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-(2-thienyl)iodonium bro...
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ژورنال
عنوان ژورنال: BMC Medical Physics
سال: 2008
ISSN: 1756-6649
DOI: 10.1186/1756-6649-8-4